Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 1.00 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.39 |
| ▸ | VEGFA | P15692 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8578347 | 0.92 | EGFR (0.85) | EGFRABL1ABL2SRCNOD1 | |
| SCHEMBL8626881 | 0.92 | EGFR (0.84) | EGFRABL1ABL2SRCMAPT | |
| SCHEMBL8575444 | 0.91 | EGFR (0.84) | EGFRABL1ABL2SRCTSHR | |
| SCHEMBL8576546 | 0.90 | EGFR (0.82) | EGFRABL1ABL2SRCPDE4D | |
| SCHEMBL8577298 | 0.88 | EGFR (0.78) | EGFRABL1ABL2SRCTSHR | |
| SCHEMBL8579701 | 0.86 | EGFR (0.79) | EGFRABL1ABL2SRC | |
| SCHEMBL8574540 | 0.83 | EGFR (1.00) | EGFRABL1ABL2SRCTSHR | |
| SCHEMBL8576451 | 0.82 | EGFR (1.00) | EGFRABL1ABL2SRCTSHR | |
| SCHEMBL8575324 | 0.82 | EGFR (0.75) | EGFRABL1ABL2SRCTSHR | |
| SCHEMBL8572765 | 0.80 | EGFR (0.75) | EGFRABL1ABL2SRCTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852011-A | Benzimidazole derivatives | MITSUI CHEMICALS, INC. (JP) | 1998-12-22 | — | — | US | disclosed |
| WO-1998017662-A1 | PHENYL-SUBSTITUTED BICYCLIC HETEROCYCLYL DERIVATIVES AND THEIR USE | NOVARTIS AG (CH) | 1998-04-30 | — | — | WO | disclosed |