Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 8/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550670 | 0.89 | MAPT (0.51) | TSHRCYP3A4MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL30084583 | 0.77 | — | — | |
| SCHEMBL52147 | 0.77 | — | — | |
| SCHEMBL1492448 | 0.76 | ALDH1A1 (0.55) | TSHRCYP3A4MAPTSMN1; SMN2NPC1 | |
| SCHEMBL3119316 | 0.75 | TAAR1 (0.54) | TSHRCYP3A4ACHEMAPTALDH1A1 | |
| SCHEMBL13344094 | 0.74 | MAPT (0.53) | TSHRCYP3A4MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL18138464 | 0.74 | MAPT (0.53) | TSHRCYP3A4MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL557939 | 0.73 | TSHR (0.72) | TSHRCYP3A4ACHEMAPTSMN1; SMN2 | |
| SCHEMBL713941 | 0.73 | TSHR (0.54) | TSHRCYP3A4MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL10662837 | 0.73 | MAPT (0.51) | TSHRCYP3A4MAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005961-A1 | COMPOUNDS HAVING A PLURALITY OF NITROGENOUS SUBSTITUENTS | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-12 | — | — | WO | disclosed |