Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | HTR3A | P46098 | 6/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | PRKCH | P24723 | 1/20 | 0.32 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | GLP1R | P43220 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8602129 | 0.78 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8572419 | 0.77 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DDDB1 | |
| SCHEMBL8601621 | 0.77 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DDDB1 | |
| SCHEMBL8603217 | 0.76 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DDDB1 | |
| SCHEMBL8603112 | 0.76 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DDDB1 | |
| SCHEMBL8602069 | 0.75 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8633013 | 0.74 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8649978 | 0.73 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8604717 | 0.73 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8669588 | 0.73 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |