Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23178137 | 0.95 | CHRNB2 (0.50) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL28485125 | 0.95 | CHRNB2 (0.50) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL30582955 | 0.95 | CHRNB2 (0.50) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL21516009 | 0.81 | CHRNB2 (0.51) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL15237647 | 0.81 | CHRNB2 (0.51) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL6131954 | 0.77 | CXCR4 (0.36) | HTR1ASLC6A2SLC6A4 | |
| SCHEMBL21516103 | 0.75 | CHRNB2 (0.50) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL31444389 | 0.75 | CHRNB2 (0.50) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL20851551 | 0.75 | CHRNB2 (0.50) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL24694986 | 0.75 | CHRNB2 (0.50) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719166-A | TREATING PSYCHOSES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1998-02-17 | — | — | US | disclosed |
| EP-0532177-B1 | Methanoanthracenes as dopamine antagonists | ZENECA LTD (GB) | 1996-10-16 | — | — | EP | disclosed |
| US-5550136-A | ANTAGONISTS OF DOPAMINE D-2 RECEPTORS | ZENECA LIMITED (GB) | 1996-08-27 | — | — | US | disclosed |
| US-5399568-A | Dopamine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-03-21 | — | — | US | disclosed |
| EP-0532177-A1 | Methanoanthracenes as dopamine antagonists | ZENECA LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |