Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Brimonidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 19/20 | 0.69 |
| ▸ | ADRA2B known ✓ | P18089 | 15/20 | 0.69 |
| ▸ | ADRA2C known ✓ | P18825 | 15/20 | 0.69 |
| ▸ | ADRA1D | P25100 | 13/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 12/20 | 0.69 |
| ▸ | ADRA1B | P35368 | 10/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | HTR1A | P08908 | 2/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.69 |
| ▸ | BLM | P54132 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Brimonidine SCHEMBL2229098 | 0.90 | ADRA2A (0.65) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Brimonidine SCHEMBL20511531 | 0.83 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Brimonidine SCHEMBL29374525 | 0.83 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Brimonidine SCHEMBL24670 | 0.83 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Brimonidine SCHEMBL22616115 | 0.82 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Brimonidine SCHEMBL1685506 | 0.82 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Brimonidine SCHEMBL14663814 | 0.80 | ADRA2A (0.65) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Brimonidine SCHEMBL16114105 | 0.78 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Brimonidine SCHEMBL4254180 | 0.77 | ADRA2A (0.82) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Brimonidine SCHEMBL1767425 | 0.77 | ADRA2A (0.82) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150297517-A1 | NEW STABLE ANESTHETIC COMPOSITION FOR REDUCING SKIN REACTIONS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2015-10-22 | — | — | US | claimed |
| US-20140205589-A1 | NEW STABLE ANESTHETIC COMPOSITION FOR REDUCING SKIN REACTIONS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2014-07-24 | — | — | US | claimed |
| EP-2726105-A1 | A NEW STABLE ANESTHETIC COMPOSITION FOR REDUCING SKIN REACTIONS | Galderma Research & Development (FR) | 2014-05-07 | — | — | EP | claimed |
| WO-2013001073-A1 | A NEW STABLE ANESTHETIC COMPOSITION FOR REDUCING SKIN REACTIONS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2013-01-03 | — | — | WO | claimed |
| EP-0828491-A1 | ARYL-IMIDAZOLINES AND ARYL-IMIDAZOLES USEFUL AS ALPHA-2 ADRENERGIC AGONISTS WITHOUT CARDIOVASCULAR SIDE EFFECTS | Allergan (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996035424-A1 | ARYL-IMIDAZOLINES AND ARYL-IMIDAZOLES USEFUL AS ALPHA-2 ADRENERGIC AGONISTS WITHOUT CARDIOVASCULAR SIDE EFFECTS | ALLERGAN (US) | 1996-11-14 | — | — | WO | disclosed |
| EP-0741709-A1 | AROMATIC 2-AMINO-IMIDAZOLE DERIVATIVES AS ALPHA-2A ADRENOCEPTOR AGONISTS | Allergan (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995019968-A1 | AROMATIC 2-AMINO-IMIDAZOLE DERIVATIVES AS ALPHA-2A ADRENOCEPTOR AGONISTS | ALLERGAN (US) | 1995-07-27 | — | — | WO | disclosed |