Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13412591 | 0.69 | NPC1 (0.71) | ALDH1A1MAPTNPC1RAB9ATSHR | |
| SCHEMBL13227995 | 0.69 | NPC1 (0.71) | ALDH1A1MAPTNPC1RAB9ATSHR | |
| SCHEMBL1994995 | 0.69 | ALDH1A1 (0.80) | ALDH1A1MAPTNPC1RAB9ATSHR | |
| SCHEMBL1937111 | 0.68 | NPC1 (0.73) | ALDH1A1MAPTNPC1RAB9ATSHR | |
| SCHEMBL13763479 | 0.68 | NPC1 (0.73) | ALDH1A1MAPTNPC1RAB9ATSHR | |
| SCHEMBL10332514 | 0.68 | NPC1 (0.73) | ALDH1A1MAPTNPC1RAB9ATSHR | |
| SCHEMBL15987948 | 0.68 | ALDH1A1 (0.73) | ALDH1A1MAPTNPC1RAB9AS1PR2 | |
| SCHEMBL10985866 | 0.68 | ALDH1A1 (0.73) | ALDH1A1MAPTNPC1RAB9AS1PR2 | |
| SCHEMBL10980499 | 0.68 | ALDH1A1 (0.73) | ALDH1A1MAPTNPC1RAB9AS1PR2 | |
| SCHEMBL17565215 | 0.68 | NPC1 (0.69) | ALDH1A1MAPTNPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915843-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSES | SMITHKLINE BEECHAM PLC (GB) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997041098-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-11-06 | — | — | WO | disclosed |