SCHEMBL8604241

SCHEMBL8604241

Clc1ccc(CCc2cccnc2)c(Cl)c1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.56
POLB P06746 1/20 0.48
CHRNA7 P36544 2/20 0.47
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
CYP1A2 P05177 1/20 0.45
CYP2D6 P10635 1/20 0.45
TBXAS1 P24557 2/20 0.45
CYP2A6 P11509 1/20 0.45
P2RX7 Q99572 2/20 0.44
HTR5A P47898 1/20 0.44
HRH4 Q9H3N8 1/20 0.44
HRH3 Q9Y5N1 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
BACE1 P56817 1/20 0.43
MARS1 P56192 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28480379 0.81 CYP1A2 (0.53) CHRNA7ALDH1A1MAPTCYP1A2CYP2D6
SCHEMBL10560920 0.80 CYP1A2 (0.62) HDAC8POLBALDH1A1CYP1A2CYP2D6
SCHEMBL5793780 0.80 NPC1 (0.57) CHRNA7MAPTCYP1A2CYP2D6CYP2A6
Hydrochloric Acid SCHEMBL30209751 0.79 CYP1A2 (0.60) HDAC8POLBALDH1A1CYP1A2CYP2D6
SCHEMBL23487457 0.78 CHRNA7 (0.55) CHRNA7MAPTCYP1A2CYP2D6TBXAS1
SCHEMBL10982083 0.77 NR1H3 (0.54) HDAC8POLBALDH1A1
SCHEMBL11621292 0.76 IDO1 (0.65) CYP1A2
SCHEMBL29485692 0.76 CHRNA7 (0.74) CHRNA7CYP1A2CYP2D6TBXAS1CYP2A6
SCHEMBL724866 0.76 CHRNA7 (0.74) CHRNA7CYP1A2CYP2D6TBXAS1CYP2A6
SCHEMBL9591185 0.75 IDO1 (0.54) POLBCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-10273483-A None JP disclosed
JP-H10273483-A 3-PYRIDYLALKYLENE COMPOUND, ITS PRODUCTION AND CONTROLLING AGENT OF PLANT DISEASE BY USING THE SAME AS ACTIVE INGREDIENT UBE IND LTD 1998-10-13 JP disclosed