Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337026 | 0.87 | SMN1; SMN2 (0.60) | SMN1; SMN2HTTLMNAASAH1TSHR | |
| SCHEMBL4769824 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2HTTLMNAASAH1TSHR | |
| SCHEMBL8760991 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2HTTLMNAASAH1TSHR | |
| SCHEMBL28044037 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2HTTLMNAASAH1RAB9A | |
| SCHEMBL8914641 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTLMNAASAH1TSHR | |
| SCHEMBL18626198 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTLMNAASAH1TSHR | |
| SCHEMBL11505841 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2HTTLMNAASAH1TSHR | |
| SCHEMBL7332230 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTLMNAASAH1TSHR | |
| SCHEMBL11419619 | 0.82 | TSHR (0.50) | SMN1; SMN2HTTLMNATSHRNPC1 | |
| SCHEMBL1577945 | 0.81 | SMN1; SMN2 (0.75) | SMN1; SMN2HTTLMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| US-5789425-A | Imidazolidinone derivatives, their acid adducts and therapeutic drugs for senile dementia | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1998-08-04 | — | — | US | disclosed |