Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8604455 | 0.87 | KDM4E (0.36) | KDM4EMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL8200743 | 0.86 | KDM4E (0.44) | KDM4EMEN1ALDH1A1LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL8601572 | 0.85 | KDM4E (0.43) | KDM4EMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL8604448 | 0.79 | KDM4E (0.32) | KDM4EMEN1ALDH1A1LMNACYP1A2 | |
| Clomethiazole SCHEMBL7346645 | 0.75 | ALDH1A1 (0.68) | KDM4EMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL6870706 | 0.73 | KDM4E (0.39) | KDM4EMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL28252395 | 0.72 | KDM4E (0.35) | KDM4EPKM | |
| SCHEMBL259320 | 0.71 | KDM4E (0.38) | KDM4EMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL23384732 | 0.70 | KDM4E (0.37) | KDM4EMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL14962449 | 0.70 | KDM4E (0.37) | KDM4EMEN1ALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0619734-B1 | NEW PHARMACEUTICAL FORMULATIONS OF 5-(2-CHLORO-1-HYDROXYETHYL)-4-METHYLTHIAZOLE | ASTRA AB (SE) | 1998-03-18 | — | — | EP | claimed |
| EP-0619734-B1 | NEW PHARMACEUTICAL FORMULATIONS OF 5-(2-CHLORO-1-HYDROXYETHYL)-4-METHYLTHIAZOLE | ASTRA AB (SE) | 1998-03-18 | — | — | EP | disclosed |
| US-5385921-A | Treatment for neurodegeneration, alzheimer's disease, huntington's chorea; antihypoxic agents, antiischemic agents | AKTIEBOLAGET ASTRA (SE) | 1995-01-31 | — | — | US | disclosed |
| EP-0619734-A1 | NEW PHARMACEUTICAL FORMULATIONS OF 5-(2-CHLORO-1-HYDROXYETHYL)-4-METHYLTHIAZOLE | Astra Aktiebolag (SE) | 1994-10-19 | — | — | EP | disclosed |
| WO-1992003134-A1 | NEW PHARMACEUTICAL FORMULATIONS OF 5-(2-CHLORO-1-HYDROXYETHYL)-4-METHYLTHIAZOLE | AKTIEBOLAGET ASTRA (SE) | 1992-03-05 | — | — | WO | disclosed |