Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.68 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.68 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.63 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8604493 | 1.00 | ADORA3 (0.68) | ADORA3ADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL12192981 | 0.93 | ADORA3 (0.79) | ADORA3ADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL19799156 | 0.93 | ADORA3 (0.79) | ADORA3ADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL2032222 | 0.92 | ADORA2A (0.77) | ADORA3ADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL9791754 | 0.88 | ADORA3 (0.87) | ADORA3ADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL26487692 | 0.88 | ADORA3 (0.60) | ADORA3ADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL9791769 | 0.88 | ADORA3 (0.87) | ADORA3ADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL9791784 | 0.88 | ADORA3 (0.87) | ADORA3ADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL8606385 | 0.85 | ADORA1 (0.86) | ADORA3ADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL8608395 | 0.85 | ADORA1 (0.86) | ADORA3ADORA2AADORA2BADORA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322242-B1 | Adenosine derivatives | GLAXO GROUP LTD (GB) | 1998-04-01 | — | — | EP | claimed |
| US-5032583-A | Cardiovascular disorders | GLAXO GROUP LIMITED (GB) | 1991-07-16 | — | — | US | disclosed |
| EP-0322242-A2 | Adenosine derivatives | GLAXO GROUP LIMITED (GB) | 1989-06-28 | — | — | EP | disclosed |