Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7456263 | 0.91 | CA12 (0.46) | PTGS2PTGS1CA12CA9 | |
| SCHEMBL7780786 | 0.82 | PTGS2 (0.50) | PTGS2PTGS1FAAHKCNH2 | |
| SCHEMBL6746898 | 0.81 | CA9 (0.43) | PTGS2PTGS1CA12CA9 | |
| SCHEMBL7456268 | 0.81 | F10 (0.38) | PTGS2PTGS1CA9 | |
| SCHEMBL6309825 | 0.80 | PTGS2 (0.39) | PTGS2PTGS1FAAHKCNH2 | |
| SCHEMBL6309288 | 0.79 | PTGS2 (0.37) | PTGS2PTGS1FAAHKCNH2 | |
| SCHEMBL7779622 | 0.74 | PTGS2 (0.58) | PTGS2PTGS1FAAHKCNH2 | |
| SCHEMBL7777961 | 0.73 | PTGS2 (0.53) | PTGS2PTGS1CA12CA9 | |
| SCHEMBL7780767 | 0.73 | PTGS2 (0.54) | PTGS2PTGS1FAAHKCNH2 | |
| SCHEMBL7779989 | 0.73 | PTGS2 (0.54) | PTGS2PTGS1FAAHKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828718-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038418-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-12-05 | — | — | WO | disclosed |