Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8606841 | 0.86 | HDAC8 (0.51) | PDE4BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7676938 | 0.81 | MAPT (0.52) | PDE4BHDAC6RAB9ALMNACA1 | |
| SCHEMBL16564105 | 0.78 | AKR1C2 (0.46) | PDE4BCA1CA2HTTMAPT | |
| SCHEMBL11292436 | 0.77 | HDAC3 (0.49) | PDE4BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL457954 | 0.75 | NPC1 (0.73) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2427418 | 0.75 | PDE4B (0.66) | PDE4BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL248073 | 0.75 | NPC1 (0.73) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL503582 | 0.74 | PDE4B (0.80) | PDE4BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10939046 | 0.74 | MMP2 (0.51) | CA1CA2HTTMAPTSMN1; SMN2 | |
| SCHEMBL4091233 | 0.73 | PDE4B (0.73) | PDE4BHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721347-A | Esters and amides of substituted pyrrole acetic acids | CELL PATHWAYS, INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0485157-A2 | Esters and amides of substituted pyrrole acetic acids | FGN, INC. (US) | 1992-05-13 | — | — | EP | disclosed |