SCHEMBL8606752

SCHEMBL8606752

C[C@@]12CCC[C@H]1[C@@H]1CCc3cc(C(=O)O)ccc3[C@H]1CC2

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SHBG P04278 2/20 0.72
STS P08842 4/20 0.62
SRD5A2 P31213 2/20 0.59
SRD5A1 P18405 1/20 0.58
HSD17B1 P14061 2/20 0.53
AKR1C3 P42330 3/20 0.53
ESR1 P03372 3/20 0.49
HSD17B10 Q99714 3/20 0.49
ESR2 Q92731 2/20 0.49
CYP3A4 P08684 2/20 0.49
LMNA P02545 2/20 0.49
CYP1A2 P05177 2/20 0.49
HIF1A Q16665 2/20 0.49
AKR1B10 O60218 1/20 0.49
PGR P06401 1/20 0.49
SERPINA6 P08185 1/20 0.49
AR P10275 1/20 0.49
MAPT P10636 1/20 0.49
CYP19A1 P11511 1/20 0.49
AKR1B1 P15121 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10535109 0.91 SHBG (0.62) SHBGSTSSRD5A2SRD5A1HSD17B1
SCHEMBL8162969 0.89 SHBG (0.59) SHBGSTSSRD5A2SRD5A1HSD17B1
SCHEMBL172746 0.84 SHBG (1.00) SHBGSTSHSD17B1ESR1HSD17B10
SCHEMBL29643366 0.84 SHBG (1.00) SHBGSTSHSD17B1ESR1HSD17B10
SCHEMBL7864592 0.84 SHBG (1.00) SHBGSTSHSD17B1ESR1HSD17B10
SCHEMBL712443 0.84 SHBG (1.00) SHBGSTSHSD17B1ESR1HSD17B10
SCHEMBL9242612 0.84 SHBG (0.63) SHBGSTSSRD5A2SRD5A1HSD17B1
SCHEMBL9238193 0.83 SRD5A2 (0.54) SHBGSTSSRD5A2SRD5A1HSD17B1
SCHEMBL10534259 0.83 SHBG (0.68) SHBGSTSHSD17B1ESR1HSD17B10
SCHEMBL9109474 0.83 STS (0.70) SHBGSTSHSD17B1ESR1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0763053-A4 STEROID DERIVATIVES FOR TREATMENT OF 5 ALPHA REDUCTASE SMITHKLINE BEECHAM CORP (US) 1998-09-09 EP disclosed
US-5618806-A STEROID 5ALPHA-REDUCTASE INHIBITOR; USEFUL FOR TREATING BENIGN PROSTATIC HYPERTROPHY, BALDNESS, ACNE, VULGURIS, SEBORRHEA, FEMALE HIRSUTISM, AND PROSTATIC ADENOCARCINOMA SMITHKLINE BEECHAM CORPORATION 1997-04-08 US disclosed
EP-0763053-A1 STEROID DERIVATIVES FOR TREATMENT OF 5 ALPHA REDUCTASE SMITHKLINE BEECHAM CORPORATION (US) 1997-03-19 EP disclosed
WO-1995033761-A1 STEROID DERIVATIVES FOR TREATMENT OF 5 ALPHA REDUCTASE SMITHKLINE BEECHAM CORPORATION (US) 1995-12-14 WO disclosed
WO-1995028413-A1 17β-SUBSTITUTED 3-CARBOXY STEROIDS THAT INHIBIT 5-α-REDUCTASE SMITHKLINE BEECHAM CORPORATION (US) 1995-10-26 WO disclosed
EP-0638090-A4 17-g(a) AND 17-g(b)-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID. SMITHKLINE BEECHAM CORP (US) 1995-10-04 EP disclosed
EP-0638090-A4 17-g(a) AND 17-g(b)-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID. SMITHKLINE BEECHAM CORP (US) 1995-10-04 EP disclosed
EP-0651643-A4 17-ALKYLKETONE STEROIDS USEFUL AS 5--g(a)-REDUCTASE INHIBITORS. SMITHKLINE BEECHAM CORP (US) 1995-10-04 EP disclosed
WO-1995021185-A1 ACYL 3-CARBOXY AROMATIC A RING STEROID AS 5-ALPHA REDUCTASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1995-08-10 WO disclosed
EP-0651643-A1 17-ALKYLKETONE STEROIDS USEFUL AS 5-$g(a)-REDUCTASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1995-05-10 EP disclosed
EP-0638090-A1 17$g(a) AND 17$g(b)-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID SMITHKLINE BEECHAM CORPORATION (US) 1995-02-15 EP disclosed
EP-0638090-A1 17$g(a) AND 17$g(b)-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID SMITHKLINE BEECHAM CORPORATION (US) 1995-02-15 EP disclosed
WO-1993022333-A1 17α AND 17β-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID SMITHKLINE BEECHAM CORPORATION (US) 1993-11-11 WO disclosed
WO-1993022333-A1 17α AND 17β-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID SMITHKLINE BEECHAM CORPORATION (US) 1993-11-11 WO disclosed
WO-1989011282-A1 AROMATIC STEROID 5-alpha-REDUCTASE INHIBITORS SMITHKLINE BECKMAN CORPORATION (US) 1989-11-30 WO disclosed