Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 6/20 | 0.32 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CCL2 | P13500 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2534262 | 0.98 | BRD4 (0.36) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| Fluoride SCHEMBL7635075 | 0.96 | BRD4 (0.35) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL393669 | 0.96 | BRD4 (0.35) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| SCHEMBL8755278 | 0.96 | BRD4 (0.35) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| Methyl Alcohol SCHEMBL7036753 | 0.94 | BRD4 (0.34) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7107311 | 0.81 | BRD4 (0.33) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8605232 | 0.79 | SIGMAR1 (0.32) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| SCHEMBL7756041 | 0.78 | BRD4 (0.36) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| SCHEMBL3383375 | 0.78 | BRD4 (0.36) | BRD4CCL2HTR2AHTR6SIGMAR1 | |
| SCHEMBL3381692 | 0.78 | BRD4 (0.36) | BRD4CCL2HTR2AHTR6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770752-A | Process for reducing the concentration of by-products in product mixtures | TARGOR GMBH (DE) | 1998-06-23 | — | — | US | disclosed |