⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860680 | 1.00 | — | — | |
| SCHEMBL859520 | 0.94 | RET (0.32) | — | |
| SCHEMBL30663357 | 0.79 | JAK2 (0.34) | — | |
| SCHEMBL1498925 | 0.78 | TYRO3 (0.44) | — | |
| SCHEMBL30100141 | 0.78 | TYRO3 (0.44) | — | |
| SCHEMBL1499317 | 0.78 | JAK2 (0.43) | — | |
| SCHEMBL1498852 | 0.78 | TYRO3 (0.44) | — | |
| SCHEMBL2088075 | 0.77 | GPR119 (0.37) | — | |
| SCHEMBL859507 | 0.77 | JAK2 (0.41) | — | |
| SCHEMBL2088076 | 0.77 | GPR119 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432555-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135650-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2010-11-25 | — | — | WO | disclosed |