Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.96 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.96 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.96 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.96 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 3/20 | 0.80 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.80 |
| ▸ | GAA | P10253 | 1/20 | 0.80 |
| ▸ | HTT | P42858 | 1/20 | 0.80 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.80 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.80 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | TP53 | P04637 | 1/20 | 0.80 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9791783 | 1.00 | ADORA3 (0.96) | ADORA3ADORA1ADORA2AADORA2BCYP2D6 | |
| SCHEMBL9791771 | 1.00 | ADORA3 (0.96) | ADORA3ADORA1ADORA2AADORA2BCYP2D6 | |
| SCHEMBL8606913 | 1.00 | ADORA3 (0.96) | ADORA3ADORA1ADORA2AADORA2BCYP2D6 | |
| SCHEMBL8606917 | 1.00 | ADORA3 (0.96) | ADORA3ADORA1ADORA2AADORA2BCYP2D6 | |
| SCHEMBL9791813 | 0.99 | ADORA3 (0.94) | ADORA3ADORA1ADORA2AADORA2BCYP2D6 | |
| SCHEMBL9791828 | 0.99 | ADORA3 (0.94) | ADORA3ADORA1ADORA2AADORA2BCYP2D6 | |
| SCHEMBL9791837 | 0.99 | ADORA3 (0.94) | ADORA3ADORA1ADORA2AADORA2BCYP2D6 | |
| Gr-79236 SCHEMBL24437080 | 0.98 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AADORA2BCYP2D6 | |
| Gr-79236 SCHEMBL12355491 | 0.98 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AADORA2BCYP2D6 | |
| Gr-79236 SCHEMBL2779193 | 0.98 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AADORA2BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322242-B1 | Adenosine derivatives | GLAXO GROUP LTD (GB) | 1998-04-01 | — | — | EP | claimed |
| US-5032583-A | Cardiovascular disorders | GLAXO GROUP LIMITED (GB) | 1991-07-16 | — | — | US | disclosed |
| EP-0322242-A2 | Adenosine derivatives | GLAXO GROUP LIMITED (GB) | 1989-06-28 | — | — | EP | disclosed |