Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL501398 | 0.83 | KMT2A (0.45) | KMT2AMEN1RXFP1GRM5AR | |
| SCHEMBL8605347 | 0.82 | KMT2A (0.44) | KMT2AMEN1RXFP1GRM5KDM4E | |
| SCHEMBL501633 | 0.80 | KMT2A (0.43) | KMT2AMEN1RXFP1GRM5ALPL | |
| SCHEMBL11072686 | 0.80 | KMT2A (0.45) | KMT2AMEN1RXFP1GRM5AR | |
| SCHEMBL8607339 | 0.78 | SCN2A (0.48) | KMT2AMEN1RXFP1GRM5AR | |
| SCHEMBL29562157 | 0.78 | RECQL (0.62) | KMT2AMEN1ARKDM4EALDH1A1 | |
| SCHEMBL5026395 | 0.78 | RECQL (0.62) | KMT2AMEN1ARKDM4EALDH1A1 | |
| SCHEMBL8607640 | 0.77 | MEN1 (0.42) | KMT2AMEN1RXFP1GRM5AR | |
| SCHEMBL3641427 | 0.76 | MEN1 (0.45) | KMT2AMEN1GRM5KDM4EALDH1A1 | |
| SCHEMBL29344067 | 0.76 | MEN1 (0.45) | KMT2AMEN1GRM5KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716964-A | BRAIN DISORDERS; ANTIISCHEMIC AGENTS | G.D. SEARLE & CO. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | disclosed |