Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL501398 | 0.81 | KMT2A (0.45) | GRM5ARALDH1A1HPGDKDM4E | |
| SCHEMBL8607629 | 0.80 | NR1H3 (0.44) | SCN2AGRM5NR1H3NR1H2ALPL | |
| SCHEMBL8605347 | 0.80 | KMT2A (0.44) | GRM5NR1H3ALDH1A1HPGDKDM4E | |
| SCHEMBL11615606 | 0.79 | NR1H3 (0.61) | SCN2AGRM5NR1H3NR1H2ALDH1A1 | |
| SCHEMBL8607285 | 0.78 | KMT2A (0.46) | GRM5ALPLARALDH1A1KDM4E | |
| SCHEMBL11072686 | 0.78 | KMT2A (0.45) | GRM5ARALDH1A1HPGDKDM4E | |
| SCHEMBL9753883 | 0.76 | SCN2A (0.43) | SCN2AGRM5NR1H3NR1H2ALPL | |
| SCHEMBL5026395 | 0.75 | RECQL (0.62) | ARALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL29562157 | 0.75 | RECQL (0.62) | ARALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL501633 | 0.75 | KMT2A (0.43) | GRM5ALPLALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716964-A | BRAIN DISORDERS; ANTIISCHEMIC AGENTS | G.D. SEARLE & CO. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | disclosed |