Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.48 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 4/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18575403 | 0.92 | SYK (0.56) | SYKATMKLK5KLK7PPARA | |
| SCHEMBL17513638 | 0.92 | SYK (0.56) | SYKATMKLK5KLK7PPARA | |
| SCHEMBL25318929 | 0.92 | SYK (0.56) | SYKATMKLK5KLK7PPARA | |
| SCHEMBL17207697 | 0.91 | SYK (0.59) | SYKATMKLK5KLK7PPARA | |
| SCHEMBL3466396 | 0.88 | SYK (0.57) | SYKATMKLK5KLK7PPARA | |
| SCHEMBL24298360 | 0.88 | SYK (0.57) | SYKATMKLK5KLK7PPARA | |
| SCHEMBL3466395 | 0.88 | SYK (0.57) | SYKATMKLK5KLK7PPARA | |
| SCHEMBL25907995 | 0.87 | SYK (0.56) | SYKATMKLK5KLK7PPARA | |
| SCHEMBL31154007 | 0.86 | SYK (0.57) | SYKATMKLK5KLK7PPARA | |
| SCHEMBL18976490 | 0.86 | SYK (0.57) | SYKATMKLK5KLK7PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680488-B1 | 2,6-DIAMINOPURINE DERIVATIVES | GLAXO GROUP LTD (GB) | 1998-04-08 | — | — | EP | disclosed |
| EP-0680488-A1 | 2,6-DIAMINOPURINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1995-11-08 | — | — | EP | disclosed |
| WO-1994017090-A1 | 2,6-DIAMINOPURINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1994-08-04 | — | — | WO | disclosed |