Sugi Predict

Sugi Predict / Compounds / SCHEMBL17207697

SCHEMBL17207697

SCHEMBL17207697

COC(=O)C[C@H](CC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C

nearest known ligand 0.59

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 1/20 0.59
▸ KLK5 Q9Y337 3/20 0.53
▸ KLK7 P49862 1/20 0.53
▸ ATM Q13315 1/20 0.53
▸ PPARA Q07869 3/20 0.50
▸ CTSS P25774 3/20 0.47
▸ ABCB1 P08183 1/20 0.47
▸ CTSL P07711 2/20 0.47
▸ MAPT P10636 1/20 0.47
▸ CTRB1 P17538 2/20 0.46
▸ PPARG P37231 2/20 0.46
▸ CTSB P07858 1/20 0.46
▸ CTSK P43235 1/20 0.46
▸ REN P00797 2/20 0.45
▸ APP P05067 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6685926 0.93 SYK (0.59) SYKKLK5KLK7ATMPPARA
SCHEMBL6685929 0.93 SYK (0.59) SYKKLK5KLK7ATMPPARA
SCHEMBL8607451 0.91 SYK (0.55) SYKKLK5KLK7ATMPPARA
SCHEMBL5224008 0.90 SYK (0.57) SYKKLK5KLK7ATMPPARA
SCHEMBL5224016 0.90 SYK (0.57) SYKKLK5KLK7ATMPPARA
SCHEMBL3276799 0.90 SYK (0.59) SYKKLK5KLK7ATMPPARA
SCHEMBL1262680 0.90 SYK (0.59) SYKKLK5KLK7ATMPPARA
SCHEMBL14119009 0.90 ATM (0.62) SYKKLK5KLK7ATMPPARA
SCHEMBL15928906 0.90 ATM (0.62) SYKKLK5KLK7ATMPPARA
SCHEMBL3108565 0.90 SYK (0.59) SYKKLK5KLK7ATMPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10329263-B2 Disubstituted 1, 2, 4-triazine compound MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-06-25 — — US disclosed
US-10029993-B2 Disubstituted 1, 2, 4-triazine compound MITSUBISHI TANABE PHARMA CORPORATION (JP) 2018-07-24 — — US disclosed
US-10029993-B2 Disubstituted 1, 2, 4-triazine compound MITSUBISHI TANABE PHARMA CORPORATION (JP) 2018-07-24 — — US disclosed
EP-3135668-A1 NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND Mitsubishi Tanabe Pharma Corporation (JP) 2017-03-01 — — EP disclosed
US-20170044115-A1 NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2017-02-16 — — US disclosed
US-20170044115-A1 NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2017-02-16 — — US disclosed
WO-2015163427-A1 NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND 田辺三菱製薬株式会社 2015-10-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10329263-B2 Disubstituted 1, 2, 4-triazine compound NR3C2, REN, NR5A1 SYK 3445/4885KLK5 712/4885KLK7 2755/4885
US-20170044115-A1 NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND NR3C2, REN, CYP21A2 SYK 3596/4885KLK5 531/4885KLK7 2445/4885
US-10029993-B2 Disubstituted 1, 2, 4-triazine compound NR3C2, REN, NR5A1 SYK 3445/4885KLK5 712/4885KLK7 2755/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.