Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 15/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.68 |
| ▸ | CCKAR | P32238 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6301539 | 0.92 | CCKBR (0.74) | CCKBRKCNH2SCN9ACCKAR | |
| SCHEMBL6310025 | 0.92 | CCKBR (0.74) | CCKBRKCNH2SCN9ACCKAR | |
| SCHEMBL9868116 | 0.89 | CCKBR (1.00) | CCKBRKCNH2CCKAR | |
| SCHEMBL9868120 | 0.89 | CCKBR (1.00) | CCKBRKCNH2CCKAR | |
| SCHEMBL4189616 | 0.87 | CCKBR (0.77) | CCKBRKCNH2SCN9ACCKAR | |
| SCHEMBL4189611 | 0.87 | CCKBR (0.77) | CCKBRKCNH2SCN9ACCKAR | |
| SCHEMBL4414763 | 0.87 | CCKBR (0.83) | CCKBRKCNH2CCKAR | |
| SCHEMBL6301977 | 0.87 | CCKBR (0.83) | CCKBRKCNH2CCKAR | |
| SCHEMBL7067691 | 0.87 | CCKBR (0.83) | CCKBRKCNH2CCKAR | |
| SCHEMBL2927644 | 0.86 | CCKBR (0.78) | CCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817658-A | ADMINISTERING A DIAZEPINE COMPOUND; DISEASES OF THE EAR | MERCK & COMPANY, INC. (US) | 1998-10-06 | — | — | US | disclosed |
| US-5776930-A | CARDIOVASCULAR DISORDERS | MERCK & COMPANY, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| EP-0730453-A4 | METHODS OF TREATING CARDIAC ARRHYTHMIA | MERCK & CO INC (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1997049690-A1 | A METHOD FOR TREATING MENIERE'S DISEASE | MERCK & CO., INC. (US) | 1997-12-31 | — | — | WO | disclosed |
| US-5597818-A | CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1997-01-28 | — | — | US | disclosed |
| US-5595990-A | TREATMENT OF CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0730453-A1 | METHODS OF TREATING CARDIAC ARRHYTHMIA | MERCK & CO. INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5428031-A | Benzodiazepine analogs; cardiovascular disorders | MERCK & CO., INC. (US) | 1995-06-27 | — | — | US | disclosed |
| US-5426185-A | Antiarrhythmia agents having reduced side effects | MERCK & CO., INC. (US) | 1995-06-20 | — | — | US | disclosed |
| WO-1995014471-A1 | ANTIARRHYTHMIC BENZODIAZEPINES | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |
| WO-1995014470-A1 | METHODS OF TREATING CARDIAC ARRHYTHMIA | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |