SCHEMBL8610344

SCHEMBL8610344

NCCc1csc2cc(Br)ccc12

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 5/20 0.56
HTR2A P28223 2/20 0.45
TRPM8 Q7Z2W7 1/20 0.45
CA2 P00918 1/20 0.42
CHEK1 O14757 2/20 0.40
TAAR1 Q96RJ0 3/20 0.38
HTR5A P47898 1/20 0.37
MAPT P10636 1/20 0.35
HDAC10 Q969S8 1/20 0.35
HDAC11 Q96DB2 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
CHRNB2 P17787 1/20 0.33
CHRNA7 P36544 1/20 0.33
CHRNA4 P43681 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8547530 0.86 CYP2A6 (0.75) CYP2A6HTR2ATRPM8CA2CHEK1
Hydrochloric Acid SCHEMBL23012014 0.85 CYP2A6 (0.73) CYP2A6HTR2ATRPM8CA2CHEK1
SCHEMBL19386570 0.80 CYP2A6 (0.51) CYP2A6CA2MAPTHDAC10HDAC11
SCHEMBL8587322 0.79 HTR2A (0.49) CYP2A6HTR2ATRPM8CA2TAAR1
SCHEMBL10424393 0.79 CYP2A6 (0.56) CYP2A6HTR2ATRPM8CA2CHEK1
SCHEMBL8589080 0.79 HTR2C (0.49) CYP2A6HTR2ATAAR1HTR5AMAPT
SCHEMBL1530170 0.79 CYP2A6 (0.50) CYP2A6CA2MAPTHDAC10HDAC11
Oxalic Acid SCHEMBL8552499 0.79 CYP2A6 (0.63) CYP2A6HTR2ATRPM8CA2CHEK1
SCHEMBL1548128 0.78 GPR35 (0.44) CYP2A6CA2MAPT
SCHEMBL16771642 0.76 CYP2A6 (0.38) CYP2A6TAAR1HTR5AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998027984-A1 METHOD OF PRODUCING ANALGESIA BY ADMINISTRATION OF 1,2,3,4-TETRAHYDROBENZO-[b]THIENO[2,3-c]PYRIDINE AND DERIVATIVES NEUREX CORPORATION (US) 1998-07-02 WO disclosed
US-4971974-A ANOREXIGENIC AGENTS, BENZO B!THIENO 2,3-C!PYRIDINE COMPOUNDS NEUREX CORPORATION (US) 1990-11-20 US disclosed