Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRA | P18433 | 1/20 | 0.58 |
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13156258 | 0.87 | PTPRA (0.49) | PTPRAFDPSSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL8613093 | 0.82 | HDAC6 (0.47) | PTPRAFDPSSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL13972048 | 0.81 | PTPRA (0.61) | PTPRAFDPSSMN1; SMN2ALDH1A1GRIN2D | |
| SCHEMBL29831780 | 0.81 | PTPRA (0.61) | PTPRAFDPSSMN1; SMN2ALDH1A1GRIN2D | |
| SCHEMBL10065593 | 0.81 | PTPRA (0.61) | PTPRAFDPSSMN1; SMN2ALDH1A1GRIN2D | |
| SCHEMBL15708508 | 0.81 | PTPRA (0.61) | PTPRAFDPSSMN1; SMN2KMT2AGRIN2D | |
| SCHEMBL3472396 | 0.81 | PTPRA (0.61) | PTPRAFDPSSMN1; SMN2ALDH1A1GRIN2D | |
| Bromide SCHEMBL17476045 | 0.80 | PTPRA (0.59) | PTPRAFDPSSMN1; SMN2ALDH1A1GRIN2D | |
| Bromide SCHEMBL17476046 | 0.80 | PTPRA (0.59) | PTPRAFDPSSMN1; SMN2ALDH1A1GRIN2D | |
| SCHEMBL28625929 | 0.80 | PTPRA (0.59) | PTPRAFDPSSMN1; SMN2ALDH1A1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |