Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.31 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL28757618 | 1.00 | TSHR (0.60) | TSHRNAPRTTDP1ALDH1A1PLOD2 | |
| Pyridine SCHEMBL8610477 | 1.00 | TSHR (0.60) | TSHRNAPRTTDP1ALDH1A1PLOD2 | |
| Pyridine SCHEMBL180736 | 1.00 | — | — | |
| Pyridine SCHEMBL10904050 | 0.97 | TSHR (0.56) | TSHRNAPRTTDP1ALDH1A1PLOD2 | |
| Pyridine SCHEMBL5579148 | 0.97 | TSHR (0.56) | TSHRNAPRTTDP1ALDH1A1PLOD2 | |
| Pyridine SCHEMBL28281060 | 0.97 | TSHR (0.56) | TSHRNAPRTTDP1ALDH1A1PLOD2 | |
| Pyridine SCHEMBL11518871 | 0.97 | TSHR (0.56) | TSHRNAPRTTDP1ALDH1A1PLOD2 | |
| Pyridine SCHEMBL28829571 | 0.97 | TSHR (0.56) | TSHRNAPRTTDP1ALDH1A1PLOD2 | |
| Pyridine SCHEMBL10950366 | 0.97 | TSHR (0.56) | TSHRNAPRTTDP1ALDH1A1PLOD2 | |
| Pyridine SCHEMBL10708687 | 0.97 | TSHR (0.56) | TSHRNAPRTTDP1ALDH1A1PLOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840758-A | USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | ABBOTT LABORATORIES (US) | 1998-11-24 | — | — | US | disclosed |