Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 8/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.47 |
| ▸ | TRHR | P34981 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9481069 | 1.00 | HDAC3 (0.47) | HDAC3HDAC11HDAC6HDAC1HDAC10 | |
| SCHEMBL6433940 | 1.00 | HDAC3 (0.47) | HDAC3HDAC11HDAC6HDAC1HDAC10 | |
| SCHEMBL6433938 | 1.00 | HDAC3 (0.47) | HDAC3HDAC11HDAC6HDAC1HDAC10 | |
| SCHEMBL9504461 | 1.00 | HDAC3 (0.47) | HDAC3HDAC11HDAC6HDAC1HDAC10 | |
| SCHEMBL8610625 | 1.00 | HDAC3 (0.47) | HDAC3HDAC11HDAC6HDAC1HDAC10 | |
| SCHEMBL31199179 | 0.95 | HDAC3 (0.47) | HDAC3HDAC11HDAC6HDAC1HDAC10 | |
| SCHEMBL29825005 | 0.87 | SMN1; SMN2 (0.41) | HDAC3HDAC11HDAC6HDAC1HDAC10 | |
| SCHEMBL10661794 | 0.87 | HDAC3 (0.43) | HDAC3HDAC11HDAC6HDAC1HDAC10 | |
| SCHEMBL31199135 | 0.86 | ACE (0.43) | HDAC3HDAC11HDAC6HDAC1HDAC10 | |
| SCHEMBL31672199 | 0.85 | TRHR (0.42) | HDAC3HDAC11HDAC6HDAC1HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674653-B1 | THERAPEUTIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES CONNECTED WITH GLUTATHIONE DEFICIENCY, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | PROSPA BV (NL) | 1998-08-12 | — | — | EP | disclosed |
| US-5736565-A | SULFUR-ACYLATED DERIVATIVES OF L-PYROGLUTAMYL-L-CYSTEINE; USEFUL FOR TREATMENT OF HEPATIC DISORDERS, INTOXICATION FROM DRUG OR CHEMICAL AGENTS, EXPOSURE TO XENOBIOTIC AGENTS, DAMAGE CAUSED BY RADIATION, BRAIN AGING, OR IMMUNE SYSTEM | PROSPA B.V. (NL) | 1998-04-07 | — | — | US | disclosed |