SCHEMBL8610673

SCHEMBL8610673

Cc1c(OO)cc2ccccc2c1C(C)C

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NCEH1 Q6PIU2 2/20 0.42
IRAK4 Q9NWZ3 1/20 0.36
CYP1A2 P05177 3/20 0.35
CYP2A6 P11509 2/20 0.35
GPR84 Q9NQS5 2/20 0.35
UGT2B7 P16662 1/20 0.33
CDK5 Q00535 1/20 0.33
CDK5R1 Q15078 1/20 0.33
TSHR P16473 1/20 0.32
TRPM4 Q8TD43 1/20 0.32
ALDH1A1 P00352 2/20 0.32
HPGD P15428 1/20 0.32
HSD17B10 Q99714 1/20 0.32
KDM4E B2RXH2 1/20 0.32
GAA P10253 1/20 0.32
NQO1 P15559 1/20 0.32
NQO2 P16083 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8609951 0.86 NCEH1 (0.44) NCEH1IRAK4CYP1A2CYP2A6GPR84
SCHEMBL28566069 0.80 CYP1A2 (0.42) NCEH1CYP1A2CYP2A6GPR84TSHR
SCHEMBL6286760 0.77 NCEH1 (0.60) NCEH1CYP1A2CYP2A6TSHRALDH1A1
SCHEMBL27051333 0.77 TRPM4 (0.48) NCEH1CYP1A2CYP2A6UGT2B7TSHR
SCHEMBL1054281 0.77 CYP1A2 (0.45) NCEH1CYP1A2CYP2A6UGT2B7TSHR
SCHEMBL8617399 0.75 CYP1A2 (0.39) NCEH1CYP1A2CYP2A6UGT2B7TSHR
SCHEMBL28130039 0.74 TRPM4 (0.52) CYP1A2CYP2A6GPR84TSHRTRPM4
SCHEMBL40806 0.73 ALDH1A1 (0.44) NCEH1CYP1A2CYP2A6UGT2B7TSHR
SCHEMBL6546711 0.71 CYP1A2 (0.47) NCEH1CYP1A2CYP2A6UGT2B7TSHR
SCHEMBL9193871 0.70 NCEH1 (0.36) NCEH1CYP1A2CYP2A6GPR84UGT2B7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0622350-B1 PROCESS FOR PRODUCING AROMATIC HYDROXYLIC COMPOUND MITSUI PETROCHEMICAL IND (JP) 1998-04-15 EP claimed
US-5475157-A Decomposing a hydroperoxide in the presence of an acid catalyst; by-product inhibition MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-12-12 US claimed
EP-0622350-A1 PROCESS FOR PRODUCING AROMATIC HYDROXYLIC COMPOUND MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-11-02 EP claimed
EP-0622350-B1 PROCESS FOR PRODUCING AROMATIC HYDROXYLIC COMPOUND MITSUI PETROCHEMICAL IND (JP) 1998-04-15 EP disclosed
US-5475157-A Decomposing a hydroperoxide in the presence of an acid catalyst; by-product inhibition MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-12-12 US disclosed
EP-0622350-A1 PROCESS FOR PRODUCING AROMATIC HYDROXYLIC COMPOUND MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-11-02 EP disclosed