Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.42 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.38 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.38 |
| ▸ | CHKA known ✓ | P35790 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8167441 | 0.97 | TDP1 (0.56) | TDP1ALDH1A1KDM4EIDO1CYP1A2 | |
| Water SCHEMBL7624991 | 0.95 | TDP1 (0.54) | TDP1ALDH1A1KDM4EIDO1CYP1A2 | |
| Hydrochloric Acid SCHEMBL6772823 | 0.95 | TDP1 (0.61) | TDP1ALDH1A1KDM4EIDO1CYP1A2 | |
| SCHEMBL10455728 | 0.95 | TDP1 (0.54) | TDP1ALDH1A1KDM4EIDO1CYP1A2 | |
| SCHEMBL10709611 | 0.95 | TDP1 (0.54) | TDP1ALDH1A1KDM4EIDO1CYP1A2 | |
| SCHEMBL10455727 | 0.95 | TDP1 (0.54) | TDP1ALDH1A1KDM4EIDO1CYP1A2 | |
| SCHEMBL10453137 | 0.92 | TDP1 (0.52) | TDP1ALDH1A1KDM4EIDO1CYP1A2 | |
| Hydrochloric Acid SCHEMBL10453138 | 0.92 | TDP1 (0.58) | TDP1ALDH1A1KDM4EIDO1CYP1A2 | |
| SCHEMBL14094644 | 0.90 | TDP1 (0.50) | TDP1ALDH1A1KDM4EIDO1CYP1A2 | |
| SCHEMBL4797252 | 0.86 | ALDH1A1 (0.68) | TDP1ALDH1A1KDM4ECHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105198698-A | Preparation method of tetrabromo cyclic di-p-xylyene | UNIV SOUTHEAST | 2015-12-30 | — | — | CN | disclosed |
| EP-0518352-B1 | Process for forming super high-contrast negative images and silver halide photographic material and developer being used therefor | DAINIPPON INK & CHEMICALS (JP) | 1998-04-22 | — | — | EP | disclosed |
| US-5460919-A | Process of forming super high-contrast negative images and silver halide photographic material and developer being used therefor | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5372911-A | Support having one or more hydrophilic colloidal layers, at least one layer contains pyridinium salt or derivative, quinolinium salt or derivative, or isoquinolinium salt or derivative | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1994-12-13 | — | — | US | disclosed |
| EP-0518352-A1 | Process for forming super high-contrast negative images and silver halide photographic material and developer being used therefor | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1992-12-16 | — | — | EP | disclosed |