SCHEMBL8611259

SCHEMBL8611259

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](OP(=O)(O)OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](O)[C@@H]2O)[C@H]1O

nearest known ligand 0.88

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RNASEL Q05823 11/20 0.88
P2RY2 P41231 4/20 0.68
P2RY1 P47900 4/20 0.65
SRC P12931 2/20 0.65
SMN1; SMN2 Q16637 2/20 0.65
P2RX1 P51575 1/20 0.65
P2RX3 P56373 1/20 0.65
P2RX4 Q99571 1/20 0.65
P2RX2 Q9UBL9 1/20 0.65
ALDH1A1 P00352 1/20 0.65
DNPH1 O43598 1/20 0.64
PRKAB2 O43741 1/20 0.64
TRPM2 O94759 1/20 0.64
LDHA P00338 1/20 0.64
ADRB2 P07550 1/20 0.64
FBP1 P09467 1/20 0.64
ADORA1 P30542 1/20 0.64
PRKAG1 P54619 1/20 0.64
PRKAA2 P54646 1/20 0.64
PDE4D Q08499 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30689044 1.00 RNASEL (0.88) RNASELP2RY2P2RY1SRCSMN1; SMN2
SCHEMBL8613078 1.00 RNASEL (0.88) RNASELP2RY2P2RY1SRCSMN1; SMN2
SCHEMBL29581821 1.00 RNASEL (0.88) RNASELP2RY2P2RY1SRCSMN1; SMN2
SCHEMBL29373108 0.96 RNASEL (0.90) RNASEL
SCHEMBL427255 0.96 RNASEL (0.93) RNASELP2RY2P2RY1SRCSMN1; SMN2
SCHEMBL29365708 0.95 RNASEL (0.82) RNASELP2RY2ADORA1
SCHEMBL22765783 0.95 RNASEL (0.82) RNASELP2RY2ADORA1
SCHEMBL24548603 0.94 RNASEL (0.77) RNASELP2RY2
SCHEMBL10496359 0.92 RNASEL (0.76) RNASELP2RY2P2RY1SRCSMN1; SMN2
SCHEMBL29524267 0.91 RNASEL (0.82) RNASELP2RY2P2RY1SRCSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5721350-A Deuterated nucleosides CHATTOPADHYAYA JYOTI (SE) 1998-02-24 US disclosed
EP-0648220-A1 DEUTERATED NUCLEOSIDES CHATTOPADHYAYA, Jyoti (SE) 1995-04-19 EP disclosed
WO-1993025566-A1 DEUTERATED NUCLEOSIDES CHATTOPADHYAYA JYOTI (SE) 1993-12-23 WO disclosed