Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4398788 | 0.87 | TP53 (0.67) | TP53CA1CA2TSHRALDH1A1 | |
| SCHEMBL8611468 | 0.85 | TP53 (0.43) | TP53CA1CA2TSHRALDH1A1 | |
| SCHEMBL8612727 | 0.82 | MAPT (0.44) | TP53CA1CA2TSHRALDH1A1 | |
| SCHEMBL14604156 | 0.81 | APP (0.43) | CA1CA2ALDH1A1CYP3A4HPGD | |
| SCHEMBL15710320 | 0.79 | ALDH1A1 (0.43) | CA1CA2ALDH1A1KDM4ELMNA | |
| SCHEMBL18686113 | 0.79 | APP (0.42) | TP53CA1CA2ALDH1A1KDM4E | |
| SCHEMBL8612683 | 0.78 | MAPT (0.46) | ALDH1A1MAPTLMNACYP3A4HSD17B10 | |
| SCHEMBL14652933 | 0.78 | CA1 (0.59) | TP53CA1CA2TSHRALDH1A1 | |
| SCHEMBL8609073 | 0.77 | HPGD (0.42) | CA2TSHRALDH1A1MAPTALOX15 | |
| SCHEMBL23108255 | 0.74 | HPGD (0.40) | TP53CA1CA2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5789623-A | Process for the preparation of hydroxybiarylphosphines and novel compounds of this group of substances | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-04 | — | — | US | disclosed |
| EP-0748811-A1 | Process for the preparation of hydroxybiarylphosphanes and novel compounds from this materials group | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-12-18 | — | — | EP | disclosed |