Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | CTSK | P43235 | 5/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22035801 | 0.83 | ALDH1A1 (0.61) | ALDH1A1CTSBSLC6A2SLC6A3KMT2A | |
| SCHEMBL29592341 | 0.81 | ALDH1A1 (0.62) | ALDH1A1CTSBSLC6A2SLC6A3KMT2A | |
| SCHEMBL11761107 | 0.81 | ALDH1A1 (0.62) | ALDH1A1CTSBSLC6A2SLC6A3KMT2A | |
| SCHEMBL22035328 | 0.81 | ALDH1A1 (0.57) | ALDH1A1SLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL11818399 | 0.80 | TSHR (0.56) | ALDH1A1CTSKKMT2ATDP1 | |
| SCHEMBL11820890 | 0.79 | KMT2A (0.47) | ALDH1A1CTSBCTSKSLC6A2SLC6A3 | |
| SCHEMBL12764091 | 0.78 | ALDH1A1 (0.56) | ALDH1A1CTSBCTSKSLC6A2SLC6A3 | |
| SCHEMBL6880665 | 0.78 | ALDH1A1 (0.67) | ALDH1A1SLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL18417659 | 0.78 | ALDH1A1 (0.56) | ALDH1A1CTSBCTSKSLC6A2SLC6A3 | |
| SCHEMBL16984518 | 0.78 | ALDH1A1 (0.56) | ALDH1A1CTSBCTSKSLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |