Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 9/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.56 |
| ▸ | HINT1 | P49773 | 2/20 | 0.56 |
| ▸ | NT5E | P21589 | 5/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8610421 | 0.93 | TYMP (0.56) | TYMPADORA1HINT1NT5E | |
| SCHEMBL8612936 | 0.91 | TYMP (0.63) | TYMPADORA1HINT1NT5E | |
| SCHEMBL8613293 | 0.91 | NT5E (0.56) | TYMPADORA1NT5EADORA2AADORA2B | |
| SCHEMBL8612754 | 0.91 | TYMP (0.67) | TYMPADORA1HINT1NT5EADORA2A | |
| SCHEMBL8613109 | 0.89 | PDE2A (0.53) | TYMPADORA1HINT1NT5E | |
| SCHEMBL8613116 | 0.89 | PDE2A (0.53) | TYMPADORA1HINT1NT5E | |
| SCHEMBL8609374 | 0.89 | TYMP (0.52) | TYMPADORA1 | |
| SCHEMBL8609070 | 0.86 | TYMP (0.51) | TYMPADORA1HINT1 | |
| SCHEMBL34927 | 0.84 | TYMP (0.64) | TYMPHINT1NT5E | |
| SCHEMBL8612269 | 0.84 | TYMP (0.55) | TYMPADORA1HINT1NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992011276-A1 | NOVEL SYNTHESIS OF 2'-'UP' FLUORINATED 2''-DEOXY-ARABINOFURANOSYLPURINES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-07-09 | — | — | WO | claimed |
| US-5750675-A | 2'-\"up\" fluorinated 2'-deoxy-arabinofuranosylpurines | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1998-05-12 | — | — | US | disclosed |
| US-5525720-A | Synthesis of 2'-\"up\" fluorinated 2'-deoxy-arabinofuranosyl purines | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1996-06-11 | — | — | US | disclosed |
| WO-1992011276-A1 | NOVEL SYNTHESIS OF 2'-'UP' FLUORINATED 2''-DEOXY-ARABINOFURANOSYLPURINES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-07-09 | — | — | WO | disclosed |