Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8612471 | 1.00 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10MEN1KMT2A | |
| SCHEMBL1404088 | 1.00 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10MEN1KMT2A | |
| SCHEMBL1404042 | 1.00 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10MEN1KMT2A | |
| SCHEMBL1404022 | 1.00 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10MEN1KMT2A | |
| SCHEMBL3922842 | 1.00 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10MEN1KMT2A | |
| SCHEMBL8616701 | 1.00 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10MEN1KMT2A | |
| SCHEMBL1404074 | 1.00 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10MEN1KMT2A | |
| SCHEMBL1404113 | 1.00 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10MEN1KMT2A | |
| SCHEMBL9075 | 0.97 | SMN1; SMN2 (0.45) | ALDH1A1LMNAHSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11579673 | 0.94 | SMN1; SMN2 (0.43) | ALDH1A1LMNAHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720597-B1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMA INC (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5693674-A | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-02 | — | — | US | disclosed |
| US-5691384-A | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis | HOECHST MARION ROUSSEL, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5684004-A | ANTINEOPLASTIC AGENTS, ANTIATHEROSCLEROTIC AGENTS, HYPOCHOLESTEROLEMIC AGENTS | MERRELL PHARMACEUTICALS, INC. (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0794771-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1997-09-17 | — | — | EP | disclosed |
| EP-0720597-A1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-10 | — | — | EP | disclosed |
| US-5525633-A | ANTITUMOR AGENTS, ANTICHOLESTEROL AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-06-11 | — | — | US | disclosed |
| WO-1996016646-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1996-06-06 | — | — | WO | disclosed |
| WO-1995008528-A1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-30 | — | — | WO | disclosed |