Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 11/20 | 0.62 |
| ▸ | GRM5 | P41594 | 11/20 | 0.62 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | EED | O75530 | 2/20 | 0.44 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.44 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.44 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2893158 | 0.80 | GRM1 (0.69) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL2239831 | 0.79 | NAMPT (0.66) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL2893091 | 0.78 | GRM1 (0.61) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL19989639 | 0.77 | NAMPT (0.67) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL2885677 | 0.77 | GRM1 (0.65) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL8614176 | 0.77 | GRM1 (1.00) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL20217955 | 0.76 | GRM1 (0.56) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL513799 | 0.76 | GPR119 (0.47) | GRM1GRM5GPR119 | |
| SCHEMBL23505457 | 0.75 | GRM1 (0.55) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL24330035 | 0.74 | PDK4 (0.52) | GRM1GRM5PDK4NAMPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712285-A | Pyrrolo-pyridine derivatives | MERCK, SHARP & DOHME, LTD. (GB) | 1998-01-27 | — | — | US | disclosed |