Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Succinimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinimide SCHEMBL30302994 | 0.86 | CRBN (0.69) | CRBNPKMNPC1MAPK13MAPK12 | |
| Succinimide SCHEMBL27863987 | 0.86 | CRBN (0.69) | CRBNPKMNPC1MAPK13MAPK12 | |
| Succinimide SCHEMBL8613393 | 0.83 | CRBN (0.65) | CRBNPKMNPC1MAPK13MAPK12 | |
| Succinimide SCHEMBL216817 | 0.81 | CRBN (0.61) | CRBNALDH1A1PKMNPC1MAPK13 | |
| Succinimide SCHEMBL217582 | 0.77 | CRBN (0.55) | CRBNALDH1A1MEN1TSHRKMT2A | |
| Succinimide SCHEMBL1326078 | 0.76 | CRBN (1.00) | CRBNALDH1A1NPC1MAPK13MAPK12 | |
| Succinimide SCHEMBL1600526 | 0.76 | — | — | |
| Succinimide SCHEMBL774 | 0.76 | — | — | |
| Sulfuric Acid SCHEMBL5145399 | 0.76 | CRBN (0.72) | CRBNALDH1A1MEN1TSHRKMT2A | |
| Sulfuric Acid SCHEMBL6537451 | 0.76 | CRBN (0.72) | CRBNALDH1A1MEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861274-A4 | CONTINUOUS PROCESS FOR POLYASPARTIC ACID SYNTHESIS | CALWOOD CHEM IND INC (US) | 1998-10-28 | — | — | EP | disclosed |
| EP-0861274-A1 | CONTINUOUS PROCESS FOR POLYASPARTIC ACID SYNTHESIS | Calwood Chemical Industries, Inc. (US) | 1998-09-02 | — | — | EP | disclosed |
| US-5688904-A | USING EFFLUENT OF AN IMMOBILIZED CELL OR ENZYME AS CATALYST | CALWOOD CHEMICAL INDUSTRIES INC. (US) | 1997-11-18 | — | — | US | disclosed |
| WO-1997018249-A1 | CONTINUOUS PROCESS FOR POLYASPARTIC ACID SYNTHESIS | CALWOOD CHEMICAL INDUSTRIES, INC. (US) | 1997-05-22 | — | — | WO | disclosed |
| US-5610264-A | Continuous process for polyaspartic acid synthesis | CALWOOD CHEMICAL INDUSTRIES, INC. (US) | 1997-03-11 | — | — | US | disclosed |