Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 13/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5639147 | 1.00 | CCR2 (0.51) | CCR2HTTRAB9AALDH1A1KDM4E | |
| SCHEMBL5638813 | 1.00 | CCR2 (0.51) | CCR2HTTRAB9AALDH1A1KDM4E | |
| SCHEMBL9087439 | 0.86 | — | — | |
| SCHEMBL5640292 | 0.81 | CCR2 (0.37) | CCR2HTTRAB9AALDH1A1KDM4E | |
| SCHEMBL8459922 | 0.76 | CCR2 (0.57) | CCR2HTTRAB9AALDH1A1NPC1 | |
| SCHEMBL327869 | 0.76 | CCR2 (0.57) | CCR2HTTRAB9AALDH1A1NPC1 | |
| SCHEMBL13649775 | 0.76 | CCR2 (0.57) | CCR2HTTRAB9AALDH1A1NPC1 | |
| SCHEMBL14010728 | 0.76 | CCR2 (0.54) | CCR2HTTRAB9AALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL31488097 | 0.74 | CCR2 (0.56) | CCR2HTTRAB9AALDH1A1NPC1 | |
| SCHEMBL7751169 | 0.73 | CCR2 (0.63) | CCR2HTTRAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |