Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.63 |
| ▸ | RXRA | P19793 | 6/20 | 0.50 |
| ▸ | RXRB | P28702 | 6/20 | 0.50 |
| ▸ | RXRG | P48443 | 5/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL475762 | 0.89 | NOTUM (0.77) | NOTUMCES2CA12CA1CA2 | |
| SCHEMBL1999038 | 0.89 | NOTUM (0.77) | NOTUMCES2CA12CA1CA2 | |
| SCHEMBL2389365 | 0.86 | RXRA (0.65) | NOTUMRXRARXRBRXRGCA12 | |
| SCHEMBL475701 | 0.85 | NOTUM (0.51) | NOTUMCES2CA12CA1CA2 | |
| SCHEMBL8506804 | 0.85 | NOTUM (0.59) | NOTUMRXRARXRBRXRGCA12 | |
| SCHEMBL8442634 | 0.85 | ERN1 (0.53) | NOTUMRXRARXRBRXRGCA12 | |
| SCHEMBL1949259 | 0.82 | CA1 (0.62) | CA12CA1CA2CA7CA9 | |
| SCHEMBL15077172 | 0.82 | NOTUM (0.68) | NOTUMCES2CA12CA1CA2 | |
| SCHEMBL2159012 | 0.82 | NOTUM (0.68) | NOTUMRXRARXRBRXRGCES2 | |
| SCHEMBL21609839 | 0.79 | NOTUM (0.64) | NOTUMCES2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731350-A | Substituted benzenedicarboxylic acid diguanides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-24 | — | — | US | disclosed |