Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1161394 | 0.80 | CYP3A4 (0.51) | CYP3A4PDE10AKDM4EALOX15TSHR | |
| SCHEMBL401474 | 0.74 | MBOAT4 (0.46) | HDAC6CYP3A4PDE10AKDM4EALOX15 | |
| SCHEMBL10827069 | 0.73 | CYP3A4 (0.46) | CYP3A4PDE10AKDM4EALOX15TSHR | |
| SCHEMBL11263830 | 0.73 | MEN1 (0.59) | HDAC6CYP3A4KDM4EALDH1A1MEN1 | |
| SCHEMBL8845824 | 0.73 | KMT2A (0.57) | CYP3A4MEN1KMT2ARXFP1EGFR | |
| SCHEMBL15457139 | 0.72 | KDM4E (0.50) | HDAC6HDAC8CYP3A4PDE10AKDM4E | |
| SCHEMBL28097945 | 0.72 | KDM4E (0.61) | CYP3A4KDM4EMEN1KMT2ARXFP1 | |
| SCHEMBL1161492 | 0.71 | KDM4E (0.49) | HDAC6HDAC8CYP3A4PDE10AKDM4E | |
| SCHEMBL404057 | 0.71 | PDE5A (0.61) | HDAC6HDAC8CYP3A4 | |
| SCHEMBL1464587 | 0.70 | EGFR (0.67) | CYP3A4KDM4EL3MBTL1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10158249-A | — | — | None | — | — | JP | disclosed |
| JP-H10158249-A | QUINAZOLINONE DERIVATIVE | OTSUKA PHARMACEUT FACTORY INC | 1998-06-16 | — | — | JP | disclosed |