SCHEMBL861450

SCHEMBL861450

CCCC(CO)Nc1nc(N)nc(C)c1Cc1ccc(C(=O)O)cc1OC

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 18/20 0.75
TLR8 Q9NR97 8/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3708640 1.00 TLR7 (0.75) TLR7TLR8
SCHEMBL16568536 0.93 TLR7 (0.75) TLR7TLR8
SCHEMBL8773395 0.93 TLR7 (0.75) TLR7TLR8
SCHEMBL15305567 0.89 TLR7 (0.80) TLR7TLR8
SCHEMBL860823 0.89 TLR7 (0.76) TLR7TLR8
SCHEMBL20515185 0.88 TLR8 (0.67) TLR7TLR8
SCHEMBL28627809 0.88 TLR8 (0.67) TLR7TLR8
SCHEMBL4201925 0.88 TLR7 (0.87) TLR7TLR8
SCHEMBL4201920 0.88 TLR7 (0.87) TLR7TLR8
SCHEMBL8818268 0.87 TLR7 (0.77) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12440560-B2 Substituted pyrimidines as vaccine adjuvants Sumitomo Pharma Co., Ltd. (JP) 2025-10-14 US disclosed
EP-3603619-B1 VACCINE ADJUVANT FORMULATION SUMITOMO PHARMA CO LTD (JP) 2025-08-13 EP disclosed
US-20240245766-A1 PYRIMIDINE COMPOUND Sumitomo Pharma Co., Ltd. (JP) 2024-07-25 US disclosed
US-11911466-B2 Substituted pyrimidines as vaccine adjuvants Sumitomo Pharma Co., Ltd. (JP) 2024-02-27 US disclosed
US-11833247-B2 Vaccine adjuvant formulation Sumitomo Pharma Co., Ltd. (JP) 2023-12-05 US disclosed
EP-3868741-B1 COMPOSITION COMPRISING A PYRIMIDINE COMPOUND AND A PATHOGEN DERIVED ANTIGEN SUMITOMO PHARMA CO LTD (JP) 2023-08-30 EP disclosed
US-20220273563-A1 VACCINE ADJUVANT FORMULATION Sumitomo Pharma Co., Ltd. (JP) 2022-09-01 US disclosed
US-20220226468-A1 PYRIMIDINE COMPOUND Sumitomo Pharma Co., Ltd. (JP) 2022-07-21 US disclosed
US-11253476-B2 Vaccine adjuvant formulation SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2022-02-22 US disclosed
CN-108290845-B Pyrimidine compounds 大日本住友制药株式会社 2021-08-03 CN disclosed
US-20200121600-A1 VACCINE ADJUVANT FORMULATION Sumitomo Pharma Co., Ltd. (JP) 2020-04-23 US disclosed
EP-3603619-A1 VACCINE ADJUVANT FORMULATION Sumitomo Dainippon Pharma Co., Ltd. (JP) 2020-02-05 EP disclosed
CN-110650729-A Vaccine adjuvant formulations 大日本住友制药株式会社 2020-01-03 CN disclosed
US-20180280499-A1 PYRIMIDINE COMPOUND Sumitomo Pharma Co., Ltd. (JP) 2018-10-04 US disclosed
EP-2432768-B1 NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES SUMITOMO DAINIPPON PHARMA CO LTD (JP) 2017-07-05 EP disclosed
US-9533978-B2 Pyrimidine derivatives and their use in the treatment of cancer and further diseases SUMITOMO DAINIPPON PHARMA CO., LTD (JP) 2017-01-03 US disclosed
US-20150080396-A1 Novel Pyrimidine Derivatives and Their Use in the Treatment of Cancer and Further Diseases DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2015-03-19 US disclosed
US-20120122867-A1 NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES ASTRAZENECA UK LIMITED (GB) 2012-05-17 US disclosed
EP-2432768-A1 NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES AstraZeneca AB (SE) 2012-03-28 EP disclosed
WO-2010133885-A1 NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES ASTRAZENECA AB (SE) 2010-11-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11833247-B2 Vaccine adjuvant formulation TLR7, TLR9, TLR5 TLR7 1/4885TLR8 4/4885
US-20120122867-A1 NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES TYMS, TYMP, DPYD TLR7 2123/4885TLR8 4294/4885
US-20240245766-A1 PYRIMIDINE COMPOUND TYMS, TYMP, DPYD TLR7 61/4885TLR8 731/4885
US-20220273563-A1 VACCINE ADJUVANT FORMULATION TLR7, TLR9, TLR5 TLR7 1/4885TLR8 4/4885
US-20220226468-A1 PYRIMIDINE COMPOUND TYMS, TYMP, DPYD TLR7 61/4885TLR8 731/4885
US-20150080396-A1 Novel Pyrimidine Derivatives and Their Use in the Treatment of Cancer and Further Diseases TYMS, TYMP, DPYD TLR7 2123/4885TLR8 4294/4885
US-11253476-B2 Vaccine adjuvant formulation TLR7, TLR9, TLR5 TLR7 1/4885TLR8 4/4885
US-20200121600-A1 VACCINE ADJUVANT FORMULATION TLR7, TLR9, TLR5 TLR7 1/4885TLR8 4/4885
US-11911466-B2 Substituted pyrimidines as vaccine adjuvants TYMS, UMPS, P2RY1 TLR7 21/4885TLR8 300/4885
US-20180280499-A1 PYRIMIDINE COMPOUND TYMS, TYMP, DPYD TLR7 61/4885TLR8 731/4885
US-12440560-B2 Substituted pyrimidines as vaccine adjuvants TYMS, UMPS, P2RY1 TLR7 21/4885TLR8 300/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.