Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8620230 | 0.99 | KMT2A (0.56) | KMT2AKDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL8617641 | 0.85 | SMN1; SMN2 (0.63) | KMT2ALMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL8616812 | 0.83 | EPHX2 (0.62) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8966762 | 0.81 | KDM4E (0.58) | KMT2AKDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL8619463 | 0.81 | NPC1 (0.59) | LMNASMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL8617471 | 0.81 | NPC1 (0.68) | KMT2ALMNAHPGDSMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL8966297 | 0.80 | KDM4E (0.56) | KMT2AKDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL8614910 | 0.78 | NPC1 (0.56) | KMT2AKDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL8618103 | 0.78 | NPC1 (0.56) | KMT2AKDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL8620355 | 0.77 | SMN1; SMN2 (0.57) | KMT2ALMNAHPGDSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |