Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.41 |
| ▸ | FRK | P42685 | 3/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8616874 | 0.98 | MPL (0.40) | MPLMAPK9EGFRMAP4K4FRK | |
| SCHEMBL1877363 | 0.76 | MAPK14 (0.62) | MPLMAPK9EGFRMAP4K4FRK | |
| SCHEMBL25184191 | 0.76 | MAPK9 (0.47) | MAPK9EGFRMAP4K4FRKCSNK1A1 | |
| SCHEMBL1444770 | 0.76 | KMO (0.51) | MPLMAPK9EGFRMAP4K4FRK | |
| SCHEMBL28296072 | 0.74 | NPC1 (0.46) | MPLMAPK9EGFRMAP4K4FRK | |
| SCHEMBL1444789 | 0.74 | EGFR (0.42) | MAPK9EGFRMAP4K4FRKCSNK1A1 | |
| SCHEMBL30141958 | 0.74 | NPC1 (0.46) | MPLMAPK9EGFRMAP4K4FRK | |
| SCHEMBL29901541 | 0.74 | KDM4E (0.50) | MAPK14HSP90AA1 | |
| SCHEMBL1356335 | 0.74 | KDM4E (0.50) | MAPK14HSP90AA1 | |
| SCHEMBL27752919 | 0.73 | ALOX5AP (0.44) | CYP2D6CASP6ROCK2ROCK1CDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101193884-A | Tubulin inhibitor and process for its preparation | WYETH CORP (US) | 2008-06-04 | — | — | CN | claimed |
| CN-100445269-C | 2-substituted pyrimidines | BASF AG (DE) | 2008-12-24 | — | — | CN | disclosed |
| CN-101268059-A | 2-substituted hydroxylaminopyrimidine, method for the production and the use thereof in the form of pesticides | BASF SE (DE) | 2008-09-17 | — | — | CN | disclosed |
| CN-101139349-A | Heterobicyclic compounds used as fungicides | BASF AG (DE) | 2008-03-12 | — | — | CN | disclosed |
| CN-100358896-C | Heterobicyclic compounds useful as fungicides | BASF AG (DE) | 2008-01-02 | — | — | CN | disclosed |
| CN-100357297-C | Pyrimidines, method for the production thereof and use thereof | BASF AG (DE) | 2007-12-26 | — | — | CN | disclosed |
| CN-1984902-A | 2-substituted pyrimidines, method for the production thereof and use thereof for controlling pathogenic fungi | BASF AG (DE) | 2007-06-20 | — | — | CN | disclosed |
| CN-1871009-A | 5-arylpyrimidines as anticancer agents | WYETH CORP (US) | 2006-11-29 | — | — | CN | disclosed |
| CN-1774439-A | Heterobicyclic compounds useful as fungicides | BASF AG (DE) | 2006-05-17 | — | — | CN | disclosed |
| CN-1768045-A | 2-substituted pyrimidines | BASF AG (DE) | 2006-05-03 | — | — | CN | disclosed |
| CN-1747958-A | Pyrimidines, methods for the production thereof, and use thereof | BASF AG (DE) | 2006-03-15 | — | — | CN | disclosed |
| WO-1998051311-A2 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-11-19 | — | — | WO | disclosed |
| CN-1069490-A | Urea derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1993-03-03 | — | — | CN | disclosed |