Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | TOP2A | P11388 | 6/20 | 0.66 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 5/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | CLK2 | P49760 | 1/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638251 | 1.00 | ALDH1A1 (0.66) | ALDH1A1TOP2ATOP2BKDM4EHPGD | |
| Hydrochloric Acid SCHEMBL10400652 | 0.99 | ALDH1A1 (0.65) | ALDH1A1TOP2ATOP2BKDM4EHPGD | |
| SCHEMBL9676493 | 0.92 | KCNH2 (0.68) | ALDH1A1TOP2ATOP2BKDM4EHPGD | |
| Hydrochloric Acid SCHEMBL9023708 | 0.91 | KCNH2 (0.67) | ALDH1A1TOP2ATOP2BKDM4EHPGD | |
| SCHEMBL10785816 | 0.90 | TOP2A (0.62) | ALDH1A1TOP2ATOP2BKDM4EHPGD | |
| SCHEMBL9668066 | 0.90 | TOP2A (0.62) | ALDH1A1TOP2ATOP2BKDM4EHPGD | |
| SCHEMBL10351473 | 0.90 | TOP2A (0.64) | ALDH1A1TOP2ATOP2BKDM4EHPGD | |
| SCHEMBL5570963 | 0.90 | ALDH1A1 (0.72) | ALDH1A1TOP2ATOP2BKDM4EHPGD | |
| SCHEMBL8433503 | 0.90 | TOP2A (0.58) | ALDH1A1TOP2ATOP2BKDM4EHPGD | |
| SCHEMBL10790810 | 0.89 | TOP2A (0.61) | ALDH1A1TOP2ATOP2BKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126355-B1 | 7-AMINO-1-CYCLOPROPYL-6,8-DIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE-CARBOXYLIC ACID, PROCESSES FOR THEIR PREPARATION AND ANTIBACTERIAL AGENTS CONTAINING THEM | BAYER AG (DE) | 1987-09-09 | — | — | EP | claimed |
| US-4659603-A | 1-CYCLOPROPYLQUINOLONE-3-CARBOXYLIC ACIDS | BAYER AKTIENGESELLSCHAFT (DE) | 1987-04-21 | — | — | US | claimed |
| US-4556658-A | 7-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acids and antibacterial agents containing these compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1985-12-03 | — | — | US | claimed |
| EP-0126355-A1 | 7-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid, processes for their preparation and antibacterial agents containing them | BAYER AG (DE) | 1984-11-28 | — | — | EP | claimed |
| JP-60126271-A | — | — | None | — | — | JP | disclosed |
| JP-60178867-A | — | — | None | — | — | JP | disclosed |
| US-20090306035-A1 | Compounds and Methods for modulating the Silencing of a Polynucleotide of Interest | EMORY UNIVERSITY (US) | 2009-12-10 | — | — | US | disclosed |
| US-20090306035-A1 | Compounds and Methods for modulating the Silencing of a Polynucleotide of Interest | EMORY UNIVERSITY (US) | 2009-12-10 | — | — | US | disclosed |
| EP-0659763-B1 | 21-Hydroxy pregnane - Quinoline carboxylic acid esters and Antibacterial and Antiinflammatory compositions containing them | SENJU PHARMA CO (JP) | 1998-05-20 | — | — | EP | disclosed |
| US-5753658-A | FOR TREATMENT OF BACTERIAL INFECTIONS | SENJU PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5672600-A | Antimicrobial dithiocarbamoyl quinolones | THE PROCTER & GAMBLE COMPANY (US) | 1997-09-30 | — | — | US | disclosed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| EP-0200307-A1 | Improved process for production of quinoline-3-carboxylic acid antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1986-11-05 | — | — | EP | disclosed |
| EP-0191185-A1 | Quinoline-carboxylic acid derivatives | DAIICHI SEIYAKU CO., LTD. (JP) | 1986-08-20 | — | — | EP | disclosed |
| US-4578473-A | Process for quinoline-3-carboxylic acid antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1986-03-25 | — | — | US | disclosed |
| US-4556658-A | 7-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acids and antibacterial agents containing these compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1985-12-03 | — | — | US | disclosed |
| JP-S60178867-A | DIHALOGENOQUINOLINE DERIVATIVE | DAI ICHI SEIYAKU CO LTD | 1985-09-12 | — | — | JP | disclosed |
| EP-0153828-A2 | 1-cyclopropyl-1, 4-dihydro-6-fluoro-4-oxo-1, 8-naphthyridine-3-carboxylic acids; their derivatives and a process for preparing the compounds | WARNER-LAMBERT COMPANY (US) | 1985-09-04 | — | — | EP | disclosed |
| JP-S60126271-A | QUINOLONECARBOXYLIC ACID DERIVATIVE | KYORIN PHARMACEUT CO LTD | 1985-07-05 | — | — | JP | disclosed |
| EP-0126355-A1 | 7-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid, processes for their preparation and antibacterial agents containing them | BAYER AG (DE) | 1984-11-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306035-A1 | Compounds and Methods for modulating the Silencing of a Polynucleotide of Interest | SNRPE, NSUN2, SNRPA | ALDH1A1 3615/4885TOP2A 1071/4885TOP2B 998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.