Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 15/20 | 0.45 |
| ▸ | RARG | P13631 | 15/20 | 0.45 |
| ▸ | RARA | P10276 | 13/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.44 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
| ▸ | GOT1 | P17174 | 1/20 | 0.44 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620346 | 0.88 | RARB (0.42) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8617706 | 0.81 | RARA (0.51) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8616987 | 0.80 | RARA (0.65) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8433273 | 0.79 | RARA (0.45) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8620100 | 0.79 | RARA (0.42) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8620103 | 0.77 | RARB (0.46) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL27437193 | 0.77 | RARA (0.53) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL6378001 | 0.77 | RARA (0.65) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8616959 | 0.75 | RARA (0.45) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8617047 | 0.75 | RARB (0.44) | RARBRARGRARACYP3A4CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679631-B1 | Biaromatic acetylated, an adamantyl group containing compounds, pharmaceutical and cosmetic compositions containing them and their use | CIRD GALDERMA (FR) | 1998-05-06 | — | — | EP | claimed |
| US-5574036-A | Adamantyl-substituted polycyclic acetylene compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1996-11-12 | — | — | US | claimed |
| US-5574036-A | Adamantyl-substituted polycyclic acetylene compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1996-11-12 | — | — | US | disclosed |