Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.40 |
| ▸ | XIAP | P98170 | 4/20 | 0.40 |
| ▸ | BIRC2 | Q13490 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8148793 | 0.81 | NOTUM (0.54) | MAPTNPC1GAARAB9AMEN1 | |
| SCHEMBL8619530 | 0.76 | TRIM24 (0.41) | TSHRMAPTNPC1GAAHTT | |
| SCHEMBL6099890 | 0.75 | NOTUM (0.54) | MAPTNPC1GAARAB9AMEN1 | |
| SCHEMBL8613836 | 0.75 | KDM1A (0.40) | TSHRMAPTNPC1GAAHTT | |
| SCHEMBL23063855 | 0.74 | CYP11B1 (0.50) | TSHRMAPTMEN1KMT2AXIAP | |
| SCHEMBL16479228 | 0.74 | NOTUM (0.66) | TSHRMAPTNPC1GAAHTT | |
| SCHEMBL8127939 | 0.73 | MAPT (0.54) | TSHRMAPTNPC1GAAHTT | |
| SCHEMBL8134991 | 0.73 | TSHR (0.51) | TSHRMAPTNPC1GAAHTT | |
| SCHEMBL8613724 | 0.73 | MAPT (0.54) | TSHRMAPTNPC1GAAHTT | |
| SCHEMBL7644001 | 0.73 | NOTUM (0.67) | TSHRMAPTNPC1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |