Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621841 | 0.90 | HRH3 (0.44) | KDM1AKDM1BTRIM24NPC1MAPT | |
| SCHEMBL8619530 | 0.85 | TRIM24 (0.41) | KDM1AKDM1BTRIM24NPC1MAPT | |
| SCHEMBL8619975 | 0.83 | KDM1A (0.38) | KDM1AKDM1BTRIM24NPC1MAPT | |
| SCHEMBL18164521 | 0.77 | HTR2A (0.43) | TRIM24MAPTHTR2AHTR2CNOTUM | |
| SCHEMBL8617073 | 0.75 | TSHR (0.45) | KDM1AKDM1BTRIM24NPC1MAPT | |
| SCHEMBL8618277 | 0.71 | HTR1A (0.47) | HTR2AHTR2C | |
| SCHEMBL8120191 | 0.70 | TRIM24 (0.50) | KDM1AKDM1BTRIM24NPC1MAPT | |
| SCHEMBL8617695 | 0.70 | NOTUM (0.43) | MAPTSMN1; SMN2EGFRNOTUMALDH1A1 | |
| SCHEMBL8615064 | 0.69 | ALDH1A1 (0.37) | MAPTHTTHTR2AHTR2CEGFR | |
| SCHEMBL23063855 | 0.67 | CYP11B1 (0.50) | MAPTSMN1; SMN2TSHRHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |