Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.89 |
| ▸ | MAPT | P10636 | 4/20 | 0.89 |
| ▸ | LMNA | P02545 | 4/20 | 0.89 |
| ▸ | MEN1 | O00255 | 4/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.89 |
| ▸ | GMNN | O75496 | 3/20 | 0.89 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.89 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.89 |
| ▸ | BLM | P54132 | 2/20 | 0.89 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.89 |
| ▸ | GLA | P06280 | 1/20 | 0.89 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.89 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.88 |
| ▸ | TP53 | P04637 | 3/20 | 0.86 |
| ▸ | TSHR | P16473 | 3/20 | 0.86 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.86 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.86 |
| ▸ | SLC25A20 | O43772 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8617144 | 1.00 | MAPK1 (0.89) | MAPK1MAPTLMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8617151 | 1.00 | MAPK1 (0.89) | MAPK1MAPTLMNAMEN1KMT2A | |
| SCHEMBL12137162 | 0.98 | CYP1A2 (0.91) | MAPK1MAPTLMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL28699980 | 0.97 | CYP1A2 (0.88) | MAPK1MAPTLMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL12002443 | 0.95 | MAPK1 (0.97) | MAPK1MAPTLMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8620437 | 0.94 | MAPK1 (1.00) | MAPK1MAPTLMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1321243 | 0.94 | MAPK1 (1.00) | MAPK1MAPTLMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8620442 | 0.94 | MAPK1 (1.00) | MAPK1MAPTLMNAMEN1KMT2A | |
| Palmitoyl-Carnitine SCHEMBL20580076 | 0.94 | MAPK1 (1.00) | MAPK1MAPTLMNAMEN1KMT2A | |
| Octanoylcarnitine SCHEMBL16535179 | 0.94 | MAPK1 (1.00) | MAPK1MAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5741816-A | CARNITINE COMPOUND | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-21 | — | — | US | disclosed |
| EP-0688555-A2 | Hair-growing agent | TANABE SEIYAKU CO., LTD. (JP) | 1995-12-27 | — | — | EP | disclosed |