SCHEMBL8617302

SCHEMBL8617302

O=C(O)CCc1ccc(N2Cc3ccccc3C2=O)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.63
NPC1 O15118 4/20 0.63
PPARD Q03181 1/20 0.60
PPARA Q07869 1/20 0.60
SMN1; SMN2 Q16637 4/20 0.57
PKM P14618 3/20 0.57
TP53 P04637 2/20 0.57
KMT2A Q03164 2/20 0.57
GAA P10253 2/20 0.57
LMNA P02545 2/20 0.57
MEN1 O00255 1/20 0.57
CYP2D6 P10635 1/20 0.57
CYP2C19 P33261 1/20 0.57
PGR P06401 1/20 0.57
CYP3A4 P08684 1/20 0.57
NFKB1 P19838 1/20 0.57
DRD1 P21728 1/20 0.57
HTT P42858 1/20 0.57
NFKB2 Q00653 1/20 0.57
RELA Q04206 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1468602 0.92 RAB9A (0.60) RAB9ANPC1PPARDPPARASMN1; SMN2
SCHEMBL6462972 0.88 RAB9A (0.57) RAB9ANPC1PPARDPPARASMN1; SMN2
SCHEMBL4200619 0.86 NPC1 (0.67) RAB9ANPC1SMN1; SMN2PKMTP53
Methane SCHEMBL11254296 0.85 NPC1 (0.65) RAB9ANPC1SMN1; SMN2PKMTP53
SCHEMBL10085912 0.82 NPC1 (0.66) RAB9ANPC1SMN1; SMN2PKMTP53
SCHEMBL11665938 0.81 NPC1 (0.63) RAB9ANPC1SMN1; SMN2PKMTP53
Propionic Acid SCHEMBL1764372 0.80 NPC1 (0.76) RAB9ANPC1SMN1; SMN2PKMTP53
SCHEMBL6453869 0.80 NPC1 (0.57) RAB9ANPC1SMN1; SMN2PKMTP53
SCHEMBL28640863 0.80 NPC1 (0.62) RAB9ANPC1SMN1; SMN2PKMTP53
SCHEMBL8330483 0.80 RAB9A (0.60) RAB9ANPC1SMN1; SMN2PKMTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5739385-A OXIDIZING AN OPTICALLY ACTIVE ALDEHYDE WITH A PERACID IN THE PRESENCE OF AN AMINE AND/OR AMINE N-OXIDE CATALYST UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1998-04-14 US claimed
US-5739385-A OXIDIZING AN OPTICALLY ACTIVE ALDEHYDE WITH A PERACID IN THE PRESENCE OF AN AMINE AND/OR AMINE N-OXIDE CATALYST UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1998-04-14 US disclosed
US-5739352-A Process for preparing carboxylic acids UNITED CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1998-04-14 US disclosed