Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | THRB | P10828 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8619180 | 0.99 | MAPT (0.69) | MAPTALDH1A1THRBTDP1KMT2A | |
| SCHEMBL8617246 | 0.89 | MAPT (0.59) | MAPTALDH1A1THRBKMT2AMEN1 | |
| SCHEMBL8614931 | 0.88 | MAPT (0.56) | MAPTALDH1A1THRBTDP1KMT2A | |
| SCHEMBL8619773 | 0.87 | MAPT (0.55) | MAPTALDH1A1THRBKMT2AMEN1 | |
| SCHEMBL8617743 | 0.85 | CYP3A4 (0.65) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8620745 | 0.84 | CYP3A4 (0.64) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL8614339 | 0.84 | CYP3A4 (0.54) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL8614859 | 0.84 | AKR1C3 (0.67) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL8613758 | 0.83 | MAPT (1.00) | MAPTALDH1A1THRBTDP1KMT2A | |
| SCHEMBL8615662 | 0.83 | MAPT (0.48) | MAPTALDH1A1KMT2AMEN1PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |