Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.68 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.66 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.66 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.66 |
| ▸ | DHODH | Q02127 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | EIF4A1 | P60842 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ELANE | P08246 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TOP1 | P11387 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900306 | 0.87 | MAPT (0.77) | MAPTALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL13977276 | 0.85 | ALDH1A1 (0.74) | MAPTALDH1A1THRBTDP1KDM4E | |
| SCHEMBL1899228 | 0.84 | EIF4A1 (0.73) | MAPTALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL8617811 | 0.83 | MAPT (0.71) | MAPTALDH1A1THRBTDP1KDM4E | |
| SCHEMBL7813091 | 0.83 | MAPT (0.70) | MAPTALDH1A1THRBTDP1KDM4E | |
| Hydrochloric Acid SCHEMBL8619180 | 0.82 | MAPT (0.69) | MAPTALDH1A1THRBTDP1KDM4E | |
| Cinchophen SCHEMBL25519 | 0.82 | KDM4E (1.00) | ALDH1A1KDM4ESMN1; SMN2LMNAPDE10A | |
| Cinchophen SCHEMBL29376617 | 0.82 | KDM4E (1.00) | ALDH1A1KDM4ESMN1; SMN2LMNAPDE10A | |
| Cinchophen SCHEMBL7588217 | 0.82 | KDM4E (1.00) | ALDH1A1KDM4ESMN1; SMN2LMNAPDE10A | |
| Cinchophen SCHEMBL4464779 | 0.80 | KDM4E (0.97) | ALDH1A1KDM4ESMN1; SMN2LMNAPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |