Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 5/20 | 0.48 |
| ▸ | PPARG | P37231 | 4/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26218121 | 0.88 | TAAR1 (0.50) | TSHRHSD17B10FDFT1PPARAPPARG | |
| SCHEMBL7774935 | 0.86 | CYP4F2 (0.56) | CYP4F2CYP4A11TSHRHSD17B10FDFT1 | |
| SCHEMBL3304286 | 0.85 | S1PR1 (0.41) | CYP4F2CYP4A11TSHRHSD17B10FDFT1 | |
| SCHEMBL1696397 | 0.82 | KDM4E (0.55) | TSHRHSD17B10FDFT1 | |
| SCHEMBL7215970 | 0.82 | PPARA (0.54) | CYP4F2CYP4A11PPARAPPARG | |
| SCHEMBL8625359 | 0.81 | FDFT1 (0.56) | CYP4F2CYP4A11TSHRHSD17B10FDFT1 | |
| SCHEMBL81474 | 0.81 | CHRM2 (0.63) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL25381878 | 0.81 | FDFT1 (0.57) | TSHRHSD17B10FDFT1 | |
| SCHEMBL176242 | 0.81 | PPARA (0.63) | PPARAPPARG | |
| SCHEMBL9819438 | 0.81 | PPARA (0.63) | PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | disclosed |