Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | TACR3 | P29371 | 4/20 | 0.48 |
| ▸ | EIF4A1 | P60842 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616636 | 0.89 | KDM4E (0.52) | TACR3CA12CA1CA2CA9 | |
| SCHEMBL8619650 | 0.86 | TSHR (0.55) | DHODHTACR3TSHRKDM4EMEN1 | |
| SCHEMBL8614044 | 0.85 | TACR3 (0.46) | TACR3TSHRCA12CA1CA2 | |
| SCHEMBL8616486 | 0.82 | TACR3 (0.47) | DHODHTACR3CA12CA1CA2 | |
| SCHEMBL8613501 | 0.81 | CA9 (0.45) | TACR3CA12CA1CA2CA9 | |
| SCHEMBL8613846 | 0.81 | KDM4E (0.67) | KDM4EMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL8615669 | 0.80 | TACR3 (0.47) | DHODHTACR3KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8619421 | 0.80 | ADORA1 (0.51) | TACR3TRPV1CA12CA1CA2 | |
| SCHEMBL8615878 | 0.80 | KDM4E (0.55) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL8615678 | 0.80 | ESR1 (0.54) | DHODHTACR3KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |